Publications

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CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motility (2023)

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The class XIV myosin of Toxoplasma gondii, TgMyoA, is druggable in an animal model of infection (2023)

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The Toxoplasma subpellicular network is highly interconnected and defines parasite shape for efficient motility and replication (2023)

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A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D (2022)

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The potent Toxoplasma gondii growth inhibitor QQ-437 does not bind to its predicted target, parasite adaptin3𝛽, in yeast three-hybrid assays (2022)

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Blocking palmitoylation of Toxoplasma gondii myosin light chain 1 disrupts glideosome composition but has little impact on parasite motility (2021)

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Differential requirements of cyclase associated protein (CAP) for actin turnover during the lytic cycle of Toxoplasma gondii (2019)

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Lightweight and Scalable Particle Tracking and Motion Clustering of 3D Cell Trajectories (2019)

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Structural and mechanistic insights into the function of the unconventional class-XIV myosin, MyoA, from Toxoplasma gondii (2018)

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Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion (2017)

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Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex (2017)

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Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo (2017)

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Not a simple tether: Binding of Toxoplasma gondii AMA1 to RON2 during invasion protects AMA1 from rhomboid-mediated cleavage and leads to dephosphorylation of its cytosolic tail (2016)

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Global Analysis of Palmitoylated Proteins in Toxoplasma gondii (2015)

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Yeast three-hybrid screen identifies TgBRADIN as a novel negative regulator of Toxoplasma gondii bradyzoite differentiation (2015)

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Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion (2014)

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Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii (2014)

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Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle (2014)

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A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility (2014)

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Identification of Cryptosporidium parvum active chemical series by repurposing the open access malaria box (2014)

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Disruption of TgPHIL1 alters specific parameters of Toxoplasma gondii motility measured in a quantitative, three-dimensional live motility assay (2014)

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A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening (2013)

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Toxoplasma gondii Chemical Biology (2013)

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Intramembrane proteolysis of Toxoplasma Apical Membrane Antigen 1 facilitates host cell invasion but is dispensable for replication (2012)

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Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion (2011)

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Targeted disruption of TgPhIL1 in Toxoplasma gondii results in altered parasite morphology and fitness (2011)

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A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity (2010)

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Toxoplasma gondii transmembrane microneme proteins and their modular design (2010)

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Synthesis and Biological Evaluation of Functionalised Tetrahydro-B-carboline Analogues as Inhibitors of Toxoplasma gondii Invasion (2009)

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GAP45 phosphorylation controls assembly of the Toxoplasma myosin XIV complex (2009)

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Identification of conoidin A as a covalent inhibitor of peroxiredoxin II (2009)

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Current and emerging approaches to studying invasion in apicomplexan parasites (2008)

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Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility (2008)

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Targeting invasion and egress: from tools to drugs? (2007)

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Synthesis and chemical characterisation of target identification reagents based on an inhibitor of human cell invasion by the parasite Toxoplasma gondii (2007)

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Laser scanning cytometer-based assays for measuring host cell attachment and invasion by the human pathogen Toxoplasma gondii (2006)

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Identification of PhIL1, a novel cytoskeletal protein of the Toxoplasma gondii pellicle, through photosensitized labeling with 5-[125I]iodonaphthalene-1-azide (2006)

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Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins (2006)

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Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion (2005)

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Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles (2005)

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The Toxoplasma gondii rhoptry protein ROP4 is secreted into the parasitophorous vacuole and becomes phosphorylated in infected cells (2004)

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A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii (2004)

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Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii (2004)

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Biosynthesis of glycosylphosphatidylinositol is essential to the survival of the protozoan parasite Toxoplasma gondii (2003)

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Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins (2002)

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Using small molecules to study big questions in cellular microbiology (2002)

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Identification and molecular characterization of GRA8, a novel, proline-rich, dense granule protein of Toxoplasma gondii (2000)

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The Toxoplasma homolog of Plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels (2000)

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Distamycin A selectively inhibits Acanthamoeba RNA synthesis and differentiation (1999)

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96-Well plates providing high optical resolution for high-throughput, immunofluorescence-based screening of monoclonal antibodies against Toxoplasma gondii (1999)

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Novel secretory pathways in Plasmodium? (1999)

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Actin-binding proteins of invasive malaria parasites and the regulation of actin polymerization by a complex of 32/34-kDa proteins associated with heat shock protein 70kDa (1998)

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Rab GTPases and the unusual secretory pathway of plasmodium (1997)

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Toxoplasma invasion: the parasitophorous vacuole is formed from host cell plasma membrane and pinches off via a fission pore (1996)

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Identification of a family of Rab G-proteins in Plasmodium falciparum and a detailed characterisation of pfrab6 (1996)

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Staurosporine inhibits invasion of erythrocytes by malarial merozoites (1994)

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Invasion of Erythrocytes by Malarial Merozoites (1994)

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The origin of parasitophorous vacuole membrane lipids in malaria-infected erythrocytes (1993)

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Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C (1990)

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The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites (1990)

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Dephosphorylation of sea urchin sperm guanylate cyclase during fertilization (1986)

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Phosphorylation of membrane-bound guanylate cyclase of sea urchin spermatozoa (1986)

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Chemotaxis of Arbacia punctulata spermatozoa to resact, a peptide from the egg jelly layer (1985)

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Effects of extracellular egg factors on sperm guanylate cyclase (1985)

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A peptide associated with eggs causes a mobility shift in a major plasma membrane protein of spermatozoa (1984)

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The increased phosphorylation of ribosomal protein S6 in Arbacia punctulata is not a universal event in the activation of sea urchin eggs (1983)

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Dephosphorylation of a major sperm membrane protein is induced by egg jelly during sea urchin fertilization (1983)

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