The class XIV myosin of Toxoplasma gondii, TgMyoA, is druggable in an animal model of infection (2022)
Kelsen, A., Kent, R.S., Snyder, A.K., Wehri, E., Bishop, S.J., Stadler, R.V., Powell, C., Martorelli di Genova, B., Rompikuntal, P.K., Boulanger, M.J., Warshaw, D.M., Westwood, N.J., Schaletzky, J., Ward, G.E.
Differential requirements of cyclase associated protein (CAP) for actin turnover during the lytic cycle of Toxoplasma gondii (2019)
Hunt, A., Wagener, J., Kent, R., Carmeille, R., Russell, M., Peddie, C., Collinson, L., Heaslip, A., Ward, G.E., Treeck, M.
Structural and mechanistic insights into the function of the unconventional class-XIV myosin, MyoA, from Toxoplasma gondii (2018)
Powell, C.J., Ramaswamy, R., Kelsen, A., Hamelin, D.J., Warshaw, D.M., Bosch, J., Burke, J.E., Ward, G.E., and Boulanger, M.J.
Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion (2017)
Whitelaw, J.A., Latorre-Barragan, F., Gras, S., Pall, G.S., Leung, J.M., Heaslip., A., Egarter, S., Andenmatten, N., Nelson, S.R., Warshaw, D.M, Ward, G.E., Meissner, M.
Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo (2017)
Gras, S., Jackson, A., Woods, S., Pall, G., Whitelaw, J., Leung, J.M., Ward, G.E., Roberts, C.W., Meissner, M.
Not a simple tether: Binding of Toxoplasma gondii AMA1 to RON2 during invasion protects AMA1 from rhomboid-mediated cleavage and leads to dephosphorylation of its cytosolic tail (2016)
Krishnamurthy, S.K., Deng, B., del Rio, R., Buchholz, K.R., Treck, M., Urban, S., Boothroyd, J., Lam, Y.-W., Ward., G.E.
Disruption of TgPHIL1 alters specific parameters of Toxoplasma gondii motility measured in a quantitative, three-dimensional live motility assay (2014)
Leung, J.M., Rould, M.A., Konradt, C., Hunter, C.A., Ward, G.E.
Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion (2014)
Leung, J.M., Tran, F., Pathak, R.B., Poupart, S., Heaslip, A.T., Ballif, B.A., Westwood, N.J.* and Ward, G.E.*
A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility (2014)
Bookwalter, C.S., Kelsen, A., Leung, J.M., Ward, G.E.* and Trybus, K.M.*
Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle (2014)
Tilley, L.D., Krishnamurthy, S., Westwood, N.J. and Ward, G.E.
A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity (2010)
Heaslip, A.T., Carey, K.L., Catti, F., Warshaw, D.M., Westwood, N.J., Ballif, B.A., Ward G.E.
Identification of conoidin A as a covalent inhibitor of peroxiredoxin II (2009)
Haraldsen, J.D., Liu, G., Botting, C.H., Walton, J.G.A., Storm, J., Phalen, T.J., Kwok, L.Y., Soldati-Favre, D., Heintz, N.H., Muller, S., Westwood, N.J., Ward, G. E.
Synthesis and chemical characterisation of target identification reagents based on an inhibitor of human cell invasion by the parasite Toxoplasma gondii (2007)
Evans, K.M., Haraldsen, J.D., Pearson, R.J., Slawin, A.M.Z, Ward, G.E., Westwood, N.J.
Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins (2006)
Brydges, S.D., Zhou, X.W., Hunyh, M., Harper, J.M., Mital, J., Ajoble, D., Daubener, W., Ward, G.E., Carruthers, V.B.
Identification of PhIL1, a novel cytoskeletal protein of the Toxoplasma gondii pellicle, through photosensitized labeling with 5-[125I]iodonaphthalene-1-azide (2006)
Gilk, S.D., Raviv, Y., Hu, K., Murray, J.M., Beckers, C.J.M., Ward, G.E.
Conditional expression of Toxoplasma gondii apical membrane antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion (2005)
Mital, J., Meissner, M., Soldati, D., Ward, G.E.
Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins (2002)
Wichroski, M.J., Melton, J., Donahue, C.G., Tweten, R.K., Ward, G.E.
The Toxoplasma homolog of Plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels (2000)
Donahue, C.G., Carruthers, V., Gilk, S.D., Ward, G.E.
Actin-binding proteins of invasive malaria parasites and the regulation of actin polymerization by a complex of 32/34-kDa proteins associated with heat shock protein 70kDa (1998)
Tardieux, I., Baines, I., Mossakowska, M., Ward, G.E.
Identification of a family of Rab G-proteins in Plasmodium falciparum and a detailed characterisation of pfrab6 (1996)
de Castro, F.A., Ward, G.E., Jambou, R., Attal, G., Jaureguiberry, G., Braun-Breton, C., Chakarabarti, D., Langsley, G.
The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites (1990)
Adams, J.H., Hudson, D.E., Torii, M., Ward, G.E., Wellems, T.E., Aikawa, M., Miller, L.H.
A peptide associated with eggs causes a mobility shift in a major plasma membrane protein of spermatozoa (1984)
Suzuki, N., Shimomura, H., Radany, E.W., Ramarao, C.S., Ward, G.E., Bentley, J.K., Garbers, D.L.